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AWS HealthOmics supports Nextflow version pinning at runtime

awsgaengineerhealthcare
feature

AWS HealthOmics now lets users specify a Nextflow engine version when starting a run via the StartRun API, allowing for controlled migration and testing of workflows. This feature provides explicit control over execution by overriding any version specified in the workflow manifest, which is particularly useful for regulated environments. It is now available across all AWS HealthOmics regions.

  • →Enable Nextflow version pinning at run time
  • →Support for multiple Nextflow versions
  • →Benefits for regulated environments and development teams
Features (1) ›
  • Enable Nextflow version pinning at run time

    AWS HealthOmics now supports specifying a Nextflow engine version via the StartRun API. This allows customers to pin runs to a specific Nextflow version for controlled migration and testing, overriding versions specified in the workflow manifest.

Enhancements (1) ›
  • Support for multiple Nextflow versions

    Customers can select from supported Nextflow versions (22.04, 23.10, 24.10, 25.10, 26.04) through the new engine-settings parameter. This provides explicit control at the point of execution and allows testing the same workflow across multiple engine versions.

Notes (1) ›
  • Benefits for regulated environments and development teams

    Version pinning is valuable for regulated environments requiring pipeline validation before upgrades. Production workflows can remain on validated versions while development teams test newer versions in parallel, reducing risks from unexpected behavior changes.

Read the original announcement →

https://aws.amazon.com/about-aws/whats-new/2026/06/aws-healthomics-nextflow-version-pinning-at-runtime/

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